šŸ“ˆ An inside look at MedTech investing in 2023

Private Capital Insider: The Weekend Edition

While everyone else is talking about the latest Zuckerberg/Musk drama, and cocaine being found in the Whitehouseā€¦

Hereā€™s the story you havenā€™t heard: After a record 2021 in Medtech venture funding ā€“ and a sharp dip in 2022 like most industries ā€“ we could be at the beginning of the next hype cycle/funding wave thanks to the ā€œJust Add AI!ā€ narrative infecting basically every industry.

But unlike the comparatively easy-to-understand business models of most hardware/software companiesā€¦

The ā€œmove fast and break thingsā€ mentality simply isnā€™t an option in a high-stakes environment like healthcare.

Medtech may offer a compelling value proposition for investors. With high barriers to entry, sophisticated technology innovations, and substantial clinical and nonclinical unmet needs to address, the industry looks like it might be set for a future of profitable growth.

Over the past three decades, the industry has outpaced the S&P index by almost 15 percentage points, with notable periods in the early 1990s, mid-2000s, and late 2010s.

Yet creating value has become more difficult in the past five years, especially for large diversified companies.

Where is there an opportunity to potentially create value?

Answer: the most expensive real estate found in most hospitals ā€“ the Operating Room.

Thatā€™s what weā€™re talking about in this Weekend Edition of Private Capital Insider.

Letā€™s dive in,

-Equifund Publishing

P.S. In case you missed it, Jake Hoffberg is going to be guest speaking at a symposium, the Surgical Investor 2023: The Operating Room of the Future on July 20-21st in Carlsbad, CA. (note, when you click that link, it will automatically subscribe you to the event guest list and youā€™ll get an email with all the details)


Weā€™ve got 10 guest passes to this exclusive event. If you happen to be in southern California during those dates and want to come, click here to get more information about the event, and how to possibly get a guest pass.

The event is an IN PERSON event that is limited to accredited investors only.

Surgical InvestorSurgical Investor 2023

The Challenge of Financing Early Stage MedTech Companies

When most investors think of early-stage investing, they usually think of the high-flying software companies that have defined Silicon Valley for the past 20-odd years.

After all, several of the most valuable stocks in the world ā€“ like Apple, Google, and Microsoft ā€“ all got early funding from venture capital firms.

But back when many of those companies were just starting, tech investing was still a very new idea, and venture capital was often the only place adventurous enough to fund these ideas.

However, the playbook for tech investing is pretty well known at this point. The software industry has greatly matured since the dot-com bust, and itā€™s not nearly as ā€œriskyā€ as it once was.

This is due in part to the entire tech ecosystem evolving and becoming more decentralized. This, in turn, has significantly brought down costs to start new tech companies.

So what's the real reason there aren't more Googles? Curiously enough, it's the same reason Google and Facebook have remained independent: money guys undervalue the most innovative startups.

The reason there aren't more Googles is not that investors encourage innovative startups to sell out, but that they won't even fund them.

I've learned a lot about VCs during the 3 years we've been doing Y Combinator, because we often have to work quite closely with them.

The most surprising thing I've learned is how conservative they are. VC firms present an image of boldly encouraging innovation.

Only a handful actually do, and even they are more conservative in reality than you'd guess from reading their sites.

I used to think of VCs as piratical: bold but unscrupulous. On closer acquaintance they turn out to be more like bureaucrats.Ā 

Maybe the VC industry has changed. Maybe they used to be bolder, but I suspect it's the startup world that has changed, not them.

The low cost of starting a startup means the average good bet is a riskier one, but most existing VC firms still operate as if they were investing in hardware startups in 1985.

They're terrified of really novel ideas, unless the founders are good enough salesmen to compensate.

But it's the bold ideas that generate the biggest returns.

Thereā€™s a lot to unpack in this statement, but perhaps the most interesting one is this...

The reason there arenā€™t more innovative startups isnā€™t because they donā€™t exist, itā€™s because the professional investors who allegedly specialize in high-risk ventures are far more conservative than they present themselves.

Even worse, their investment models are based on old paradigms that arenā€™t necessarily useful in todayā€™s investment landscape.

For tech companies, itā€™s pretty easy to see how radically early-stage funding has changed over the past 20 years.

In the early 2000s, there was already a well-developed ecosystem of VCs in Silicon Valleyā€¦

But they tended to prefer to fund companies that seemed like a ā€œsure thingā€ instead of taking a chance on risky startups with unproven technical founders.

And because these VCs were pretty much the only game in town funding deals, they dictated the terms.

For the founders, this meant they usually had to agree to non-founder-friendly terms from the VCs in order to get fundingā€¦

And had the very real risk of being ousted from their company and being replaced by the VCā€™s favorite band of suits.

But then, the modern tech infrastructure started to developā€¦

A combination of open-source software, modern web frameworks, SaaS developer tools, cloud hosting, and better distribution channels made it easier for Founders to start developing their products.

This meant technical founders who couldnā€™t raise money from VCs from the power of an idea could instead bootstrap their way to a ā€œminimum viable productā€ to get early traction (and then funding).

This, in turn, shifted the balance of power into the founders' favor, and in turn, began to change the entire fundraising landscape for tech companies (and the types of deals founders could negotiate).

Easy access to flexible, institutional seed funding led to an explosion of tech startups, and today this is the default path for tech startups to get started.

However, in MedTech, itā€™s not like you can max out your credit cards, quickly build a new drug or device, test it on a bunch of people, and hope for the best.

In many cases, it requires millions of dollars, and years of work, before a product can be taken to market and commercialized.

Not to mention, those multi-million dollar check sizes often mean non-founder-friendly deal terms.

But in the same way the technology ecosystem brought down costs by creating new infrastructureā€¦

Weā€™re starting to see the same thing happen in the world of medicine.

Iā€™ve noticed that raising money for a biotech or other life science company in 2019 looks a lot like raising money for a tech company 10 years ago.

Since then, fundamental forces caused fundraising for tech companies to change dramatically.

And I believe that they are going to change biotech fundraising very much the way they changed tech company fundraising.

Because you can start cheaply, itā€™s now possible to start a biotech company the way people start a tech company.

By raising money incrementally, rather than a giant amount upfront, you can keep control of your company.

It should come as no surprise that we here at Equifund like this general trend towards raising money incrementallyā€¦

But what we find more interesting is the idea of who has control over the company.

Why? Because if the goal of healthcare innovation is to improve healthcare outcomes while also reducing costs, there is an obvious conflict of interest between profit-seeking investors, and the realities of our ballooning healthcare spending in America.

So how do we think about balancing the seemingly at-odds motivations of patients, physicians, payors, providers, and investors?

If we believe that itā€™s easier to improve portfolio returns by reducing fee drag than it is by increasing riskā€¦

Reducing expense drag serves a similar function of improving company profit margins without having to increase revenue.

For this reason, if the goal is to provide better care at lower costs, I think itā€™s reasonable to say that itā€™s probably easier to achieve this goal through better cost controls than it is a breakthrough technology.

For example, for virtually every procedure studied, 30% are unnecessary if clinicians use rigorous appropriateness criteria.

And even though many believe that new technologies are the ā€˜magic bulletā€™ needed to reduce the financial pressure on healthcare systems while, at the same time, enhancing patient outcomesā€¦

Surgeons have also eagerly adopted new technology, which may add to treatment costs without meaningful improvements in outcomes, even if the surgical treatment itself is indicated.

In fact, many surgical procedures are performed at expensive inpatient facilities when they could be performed at an ambulatory center for 50% less.

Thatā€™s why there may be more opportunity in this tiny 600 sqft surgical theatre to increase efficiency, lower costs, and deliver better patient outcomes.

There are many peer-reviewed journal articles regarding cost savings in surgery, but there is little consensus on the amount of savings and the variables that come into play.

Nowhere is this more clear than the operating room; Multiple per minute estimates exist from <$10/minute to >$100/minute.

ORs are often so cramped with no space to walk in and people climbing over carts and bending over equipment, which makes for an extremely unsafe environment.

Even worse, U.S. healthcare system spends $1.4 trillion annually ā€” one-third of healthcare costs ā€” on defects, such as surgical errors (e.g., wrong-side surgery), poor outcomes (e.g., sepsis), or ineffective care (e.g., tumor recurrence) undermine value.

In fact, many surgical procedures are performed at expensive inpatient facilities when they could be performed at an ambulatory center for 50% less.

Opportunity Costs of Defects in Value

When health systems spend above the cost-effectiveness threshold in a low- or no-value care situation, each dollar spent is a dollar lost that might provide clinical benefits to other patients.

When we spend below the threshold in the high-value care zone, we deliver clinically beneficial care to patients most of the time.

Moreover, we free up resources that allow health systems to deliver the best available care to the patient in the operating room and the next patient in the waiting room.

Thatā€™s why for the entrepreneurs and investors who can develop new ways to potentially save thousands of dollars per surgery comes an opportunity to unlock billions of dollars in healthcare savings (and potential market cap).

With so many new technologies and techniques working their way into OR, one question is at the forefront:

Who will pay for these new technologies?

The most likely answer: if the investor community isnā€™t willing to fund these innovations, the costs will inevitably fall onto the patients.

So if youā€™re the kind of person who likes to be on the cutting edge of technology, now might be a more advantageous time to consider investing in medical device companies that can help deliver...

Better healthcare outcomes at lower prices!

Letā€™s not mince words. Healthcare costs are spiraling out of control and something needs to be done about it.

This likely means more innovative medical device companies may need to be funded ā€“ and successfully commercialized ā€“ if weā€™re going to tackle the problems we face with our aging population and ballooning healthcare costs.

But launching new medical devices isnā€™t easy. It requires time, money, clinical data, regulatory approval, and crucially, support from clinicians within the system.

The visionary founders arenā€™t the ā€œtech brosā€ of Silicon Valleyā€¦

Theyā€™re practitioners who are building and implementing new solutions that attempt to create ā€œwin-win-win-win-winā€ solutions for the patients, physicians, healthcare providers, payors, and investors.

And thatā€™s what Iā€™m going to be talking about at the upcoming Operating Room of the Future on July 20-21st.

Want to be my +1 to the OR of the Future?

Surgical InvestorSurgical Investor 2023

Again, the event is free of charge and by invitation only. Also, you must be an accredited investor, qualified purchaser, or fund manager to attend.

Iā€™ve got 10 guest passes and need to know by Friday (7/14) who Iā€™ll be giving them to.

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